An androgen-inducible proximal tubule-specific Cre recombinase transgenic model
نویسندگان
چکیده
منابع مشابه
An androgen-inducible proximal tubule-specific Cre recombinase transgenic model.
To facilitate the study of renal proximal tubules, we generated a transgenic mouse strain expressing an improved Cre recombinase (iCre) under the control of the kidney androgen-regulated protein (KAP) promoter. The transgene was expressed in the kidney of male mice but not in female mice. Treatment of female transgenic mice with androgen induced robust expression of the transgene in the kidney....
متن کاملInnovative Methodology An androgen-inducible proximal tubule-specific Cre recombinase transgenic model
Li H, Zhou X, Davis DR, Xu D, Sigmund CD. An androgeninducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol 294: F1481–F1486, 2008. First published April 2, 2008; doi:10.1152/ajprenal.00064.2008.—To facilitate the study of renal proximal tubules, we generated a transgenic mouse strain expressing an improved Cre recombinase (iCre) under the control of the...
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BACKGROUND Podocytes play an important role in maintaining normal glomerular function. A podocyte-specific conditional knockout technology has been established by the use of transgenic mice expressing a podocyte-specific Cre recombinase to clarify the role of genes expressed in the podocytes. However, it may be difficult to examine the role of genes in certain pathologic conditions using conven...
متن کاملPodocyte-specific expression of cre recombinase in transgenic mice.
We report a transgenic mouse line that expresses Cre recombinase exclusively in podocytes. Twenty- four transgenic founders were generated in which Cre recombinase was placed under the regulation of a 2.5-kb fragment of the human NPHS2 promoter. Previously, this fragment was shown to drive beta-galactosidase (beta-gal) expression exclusively in podocytes of transgenic mice. For analysis, founde...
متن کاملSpecific Cre/Lox recombination in the mouse proximal tubule.
The present work reports for the first time the construction of a transgenic mouse strain with specific expression of Cre recombinase in the kidney proximal tubule. A Cre/loxP strategy was developed using sglt2 promoter to drive Cre recombinase expression in transgenic mice. The mouse sglt2 5' region consisting of the first exon, the first intron, and part of the second exon was cloned upstream...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2008
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00064.2008